Description

(Thr6)-Bradykinin CAS NO 6120-63-4 is a synthetic peptide analog of the endogenous vasoactive nonapeptide bradykinin, modified at the sixth position with a threonine residue. This modification is of significant interest for research into the structure-activity relationships of kinin receptors and their role in physiological and pathological processes. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in cardiovascular research, inflammation studies, and neuropharmacology.

Application

• Biomedical Research: A critical tool for investigating the bradykinin B1 and B2 receptor signaling pathways, their activation mechanisms, and downstream effects.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the development of novel analgesics, anti-inflammatory agents, and cardiovascular drugs targeting the kallikrein-kinin system.
• Pharmacological Studies: Used in in vitro and in vivo assays to study vasodilation, blood pressure regulation, pain perception, and inflammatory responses.
• Biochemical Analysis: Employed in enzyme kinetics studies, receptor binding assays (competitive displacement), and as a substrate for peptidase activity tests.
• Academic & Clinical Research: Fundamental for exploring the peptide's role in conditions like sepsis, hereditary angioedema, chronic pain, and cancer.

Basic Information

Product Name	(Thr6)-Bradykinin
CAS No.	6120-63-4
Molecular Formula	C50H73N15O11
Molecular Weight	1060.2 g/mol
Synonyms	Bradykinin, Thr(6)-; [Thr6]-Bradykinin; H-Arg-Pro-Pro-Gly-Phe-Thr-Pro-Phe-Arg-OH; Threonine6-bradykinin; Kallidin I (Thr6); Polypeptide BPP5a; RPPGFTPFR; Nonapeptide BPP 5a
EINECS	Contact for details

Quality Control

Our (Thr6)-Bradykinin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes to ensure consistency and reliability for your research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content (AAA)	≥ 80%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.