Description

n-Formyl-L-Leucine is a protected derivative of the essential amino acid L-leucine, where the amino group is blocked by a formyl moiety. This modification is critical for its primary role as a key chiral building block and intermediate in the synthesis of complex peptides, pharmaceuticals, and fine chemicals. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced organic synthesis sectors who require high-purity, stereochemically defined intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for peptide-based drugs and enzyme inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis as a protected leucine derivative to prevent unwanted side reactions during coupling steps.
• Biochemical Research: Serves as a substrate or precursor in enzymatic studies and metabolic pathway research.
• Fine Chemical Production: An intermediate for manufacturing specialty chemicals, agrochemicals, and advanced materials requiring specific stereochemistry.
• Protecting Group Chemistry: The formyl group can be selectively removed under mild conditions, making it valuable in multi-step synthetic sequences.

Basic Information

Product Name	n-Formyl-L-Leucine
CAS No.	6113-61-7
Molecular Formula	C7H13NO3
Molecular Weight	159.18 g/mol
Synonyms	N-Formyl-L-leucine; L-Leucine, N-formyl-; (S)-2-Formamido-4-methylpentanoic acid; Formylleucine; F-Leu-OH; N-For-Leu-OH; Leucine, N-formyl-; NSC 3349
EINECS	Contact for details

Quality Control

Our n-Formyl-L-Leucine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical and research applications. Certificates of Analysis (COA) detailing specific results for purity, optical rotation, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	-20.0° to -24.0° (c=1 in AcOH)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.