Description

D-Threo-Sphingosine is a high-purity, stereochemically defined sphingolipid backbone essential for cellular signaling and membrane structure. This compound serves as a critical building block and research tool for investigating sphingolipid metabolism, apoptosis, and cell proliferation pathways. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for drug discovery, biochemical studies, and the synthesis of complex sphingolipids.

Application

• Biochemical Research: A fundamental tool for studying ceramide and sphingosine-1-phosphate (S1P) signaling pathways, cell growth, and programmed cell death (apoptosis).
• Pharmaceutical Intermediates: Serves as a key chiral precursor in the synthesis of novel therapeutic agents targeting cancer, inflammation, and neurological disorders.
• Lipidomics Standards: Used as a certified reference standard in mass spectrometry for the accurate quantification and profiling of sphingolipids in biological samples.
• Cell Culture & Media Supplements: Employed in specialized cell culture applications to modulate membrane fluidity and study lipid raft dynamics.
• Enzyme Substrate: Acts as a substrate for kinases (e.g., sphingosine kinase) and other enzymes involved in sphingolipid metabolism for assay development and inhibitor screening.
• Cosmeceutical Research: Investigated for its potential role in skin barrier function and as an active ingredient in advanced dermatological formulations.

Basic Information

Product Name	D-Threo-Sphingosine
CAS No.	6036-85-7
Molecular Formula	C18H37NO2
Molecular Weight	299.49 g/mol
Synonyms	(2S,3R)-2-Amino-3,4-dihydroxyoctadec-4-ene; (2S,3R)-2-Amino-1,3-dihydroxy-4-octadecene; Erythro-sphingosine; D-erythro-Sphingosine; Sphing-4-enine; Sphingenine; SPH; trans-4-Sphingenine; (E)-Sphing-4-enine
EINECS	227-907-5

Quality Control

Our D-Threo-Sphingosine is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity. Each lot is subjected to comprehensive analytical testing, including chiral purity verification, to meet the exacting standards required for research and synthesis. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profiles is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% D-erythro isomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.