Description

L-Homocysteine is a sulfur-containing, non-proteinogenic amino acid that serves as a critical intermediate in the methionine cycle. Its precise measurement and availability are essential for research into cardiovascular health, metabolic disorders, and neurological function. This high-purity biochemical is primarily utilized by pharmaceutical R&D laboratories, diagnostic kit manufacturers, and academic institutions conducting studies on homocysteinemia and related biomarkers.

Application

• Biochemical Research & Diagnostic Assays: A key standard and reagent for quantifying homocysteine levels in plasma/serum, vital for cardiovascular risk assessment and metabolic studies.
• Pharmaceutical Intermediates: Serves as a crucial building block in the synthesis of more complex molecules and potential therapeutic agents targeting homocysteine-related pathways.
• Cell Culture & Microbiology: Used in defined media formulations to study sulfur amino acid metabolism in various cell lines and microbial systems.
• Nutritional Science: Employed in research investigating the impact of vitamins B6, B12, and folate on homocysteine metabolism and dietary interventions.
• Reference Standard: Acts as a primary standard for calibration in High-Performance Liquid Chromatography (HPLC), Liquid Chromatography-Mass Spectrometry (LC-MS), and other analytical methods.
• Enzymology Studies: A substrate for enzymes such as cystathionine β-synthase (CBS) in the study of transsulfuration pathways.

Basic Information

Product Name	L-Homocysteine
CAS No.	6027-13-0
Molecular Formula	C4H9NO2S
Molecular Weight	135.19 g/mol
Synonyms	(S)-2-Amino-4-mercaptobutyric acid; L-2-Amino-4-mercaptobutyric acid; Hcy; L-Hcy; Homocysteine; (S)-Homocysteine; 2-Amino-4-sulfanylbutanoic acid
EINECS	227-854-7

Quality Control

Our L-Homocysteine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements of research and diagnostic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and reliability for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	-3.5° to -5.0° (c=1 in 1N HCl)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.