Description

L-Histidine Dihydrochloride is the dihydrochloride salt form of the essential amino acid L-Histidine, a critical building block for proteins and peptides. This high-purity derivative offers enhanced solubility and stability, making it a preferred choice for demanding formulation and synthesis processes. It is primarily utilized in the pharmaceutical, nutraceutical, and biochemical research sectors where precise quality and reliable supply are paramount.

Application

• Pharmaceutical Intermediates & API Synthesis: A key chiral building block in the production of active pharmaceutical ingredients (APIs) and complex peptide drugs.
• Cell Culture Media & Bioprocessing: An essential nutrient component in mammalian and microbial cell culture media for biopharmaceutical manufacturing.
• Dietary Supplements & Clinical Nutrition: Used in parenteral nutrition solutions and specialized amino acid supplement formulations.
• Biochemical Research & Diagnostics: Serves as a standard and reagent in enzymatic studies, metabolic research, and diagnostic kit production.
• Cosmetic & Personal Care: Incorporated into high-end skincare formulations for its purported skin-conditioning and antioxidant properties.

Basic Information

Product Name	L-Histidine Dihydrochloride
CAS No.	6027-02-7
Molecular Formula	C6H9N3O2 • 2HCl
Molecular Weight	228.10 g/mol
Synonyms	L-Histidine HCl; Histidine Dihydrochloride; (S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid dihydrochloride; H-His-OH•2HCl; L-Histidine hydrochloride; Histidine monohydrochloride (common misnomer); Histidine dihydrochloride monohydrate (hydrated form); L-Histidine, dihydrochloride
EINECS	227-886-3

Quality Control

Our L-Histidine Dihydrochloride is manufactured under a strict quality management system. It is typically produced to meet or exceed relevant industry standards for high-purity amino acid derivatives, including potential compliance with USP-NF, EP, and FCC monographs where applicable. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the original container must be kept tightly sealed after use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.5%
Specific Rotation [α]D20	+8.5° to +10.5° (c=2 in H2O)
pH (1% Solution)	2.0 - 4.0
Loss on Drying	≤ 0.5%
Residue on Ignition (Sulfated Ash)	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.