Description

3,4-Difluorobenzyl Chloride is a versatile and high-purity fluorinated benzyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the aromatic ring, which significantly influences the electronic properties and metabolic stability of final target molecules. This compound is essential for research and production in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients.

Application

3,4-Difluorobenzyl Chloride is a key synthetic intermediate prized for its reactivity and the unique properties imparted by its difluoro substitution pattern. Its primary applications include:

• Pharmaceutical Intermediates: Synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, CNS agents, and anti-cancer drugs where the difluorobenzyl moiety enhances potency and bioavailability.
• Agrochemical Synthesis: Manufacturing of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atoms to improve lipophilicity and environmental stability.
• Liquid Crystal Materials: Used in the production of fluorinated liquid crystals for high-performance displays (LCDs).
• Organic Electronic Materials: Acting as a precursor for materials used in organic light-emitting diodes (OLEDs) and semiconductors.
• Functional Dyes and Pigments: Incorporation into dye molecules to alter light absorption and improve fastness properties.
• Cross-coupling Reactions: Serves as an electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct complex biaryl systems.

Basic Information

Product Name	3,4-Difluorobenzyl Chloride
CAS No.	698-80-6
Molecular Formula	C7H5ClF2
Molecular Weight	162.56 g/mol
Synonyms	1-(Chloromethyl)-3,4-difluorobenzene; (3,4-Difluorophenyl)methyl chloride; α-Chloro-3,4-difluorotoluene; 3,4-Difluoro-α-chlorotoluene; 3,4-DFBC; 698-80-6; Benzene, 1-(chloromethyl)-3,4-difluoro-
EINECS	211-823-7

Quality Control

Our 3,4-Difluorobenzyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our production adheres to cGMP principles where applicable, ensuring reliability for critical pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases, strong oxidizing agents, and strong acids. Recommended storage temperature is 2-8°C for long-term stability. The compound is moisture-sensitive; keep container tightly sealed under an inert atmosphere (e.g., nitrogen) to prevent hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Purity (HPLC)	≥ 97.5%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.32 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.