Description

5-Chloro-2,4,6-trifluoropyrimidine is a versatile halogenated pyrimidine building block of significant importance in advanced organic synthesis. Its value lies in its trifluoromethyl and chloro substituents, which make it a key intermediate for introducing fluorinated motifs into target molecules. This compound is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by manufacturers of specialty materials and liquid crystals.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity, metabolic stability, and lipophilicity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the production of advanced polymers, liquid crystals, and electronic materials requiring specific fluorinated aromatic structures.
• Cross-Coupling Reactions: The chlorine atom provides an excellent handle for further functionalization via metal-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to create complex biaryl systems.
• Nucleophilic Aromatic Substitution: The fluorine atoms, especially those ortho to the nitrogen, are susceptible to nucleophilic displacement, allowing for the introduction of a variety of amines, alkoxides, and thiols.
• Chemical Research & Development: Employed in academic and industrial labs as a standard reagent for exploring new fluorination methodologies and constructing diverse heterocyclic libraries for screening.

Basic Information

Product Name	5-Chloro-2,4,6-trifluoropyrimidine
CAS No.	697-83-6
Molecular Formula	C4ClF3N2
Molecular Weight	180.51 g/mol
Synonyms	2,4,6-Trifluoro-5-chloropyrimidine; 5-Chloro-2,4,6-trifluoro-1,3-diazine; Pyrimidine, 5-chloro-2,4,6-trifluoro-; 5-Chloro-2,4,6-trifluoropyrimidine; 5-Chloro-2,4,6-trifluoro-1,3-diazabenzene
EINECS	Contact for details

Quality Control

Our 5-Chloro-2,4,6-trifluoropyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.