Description

n-ε-Acetyl-L-Lysine is a chemically modified derivative of the essential amino acid L-Lysine, featuring an acetyl group on its ε-amino side chain. This specific modification is crucial for biochemical research and pharmaceutical development, as it serves as a key building block and a model compound for studying post-translational modifications like acetylation. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications in peptide synthesis, proteomics, and as a reference standard in analytical chemistry.

Application

• Pharmaceutical Intermediate: A key raw material in the synthesis of more complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a standard and reagent in proteomics research to study lysine acetylation, a critical post-translational modification involved in gene regulation and cell signaling.
• Peptide Synthesis: Serves as a protected lysine derivative in solid-phase and solution-phase peptide synthesis to prevent unwanted side-chain reactions.
• Reference Standard: Employed as a high-purity chromatographic reference standard for quality control and method development in analytical laboratories (HPLC, LC-MS).
• Enzyme Substrate Studies: Acts as a substrate for studying the activity of deacetylase enzymes (e.g., sirtuins, HDACs) in drug discovery programs.
• Nutritional Science Research: Investigated in studies concerning modified amino acids and their metabolic fate or nutritional bioavailability.

Basic Information

Product Name	n-ε-Acetyl-L-Lysine
CAS No.	692-04-6
Molecular Formula	C8H16N2O3
Molecular Weight	188.22 g/mol
Synonyms	Nε-Acetyl-L-lysine; N6-Acetyl-L-lysine; ε-Acetyl-L-lysine; Ac-Lys-OH; (S)-2-Amino-6-acetamidohexanoic acid; L-Lysine, N6-acetyl-; H-Lys(Ac)-OH; N-ε-Acetyllysine
EINECS	211-724-3

Quality Control

Our n-ε-Acetyl-L-Lysine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets high-grade specifications suitable for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]20/D: +18.0° to +22.0° (c=1 in H2O)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Chiral Purity (HPLC)	≥99.0% L-Isomer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.