Description

H-Leu-Nh2 CAS NO 687-51-4 is a high-purity, protected amino acid derivative, specifically the amide of N-Boc-L-leucine. This compound serves as a critical chiral building block in the synthesis of complex peptides and active pharmaceutical ingredients (APIs). It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality intermediates for advanced organic synthesis.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the production of peptide-based drugs and therapeutic agents.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce the leucine residue with a protected amine group.
• Bioconjugation: Acts as a linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Proteomics Research: Employed in biochemical research for studying enzyme inhibitors and designing novel bioactive peptides.
• Fine Chemical Production: Intermediate in the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.

Basic Information

Product Name	H-Leu-Nh2 CAS NO 687-51-4
CAS No.	687-51-4
Molecular Formula	C11H22N2O3
Molecular Weight	230.31 g/mol
Synonyms	Boc-L-leucinamide; (S)-2-((tert-Butoxycarbonyl)amino)-4-methylpentanamide; N-Boc-L-leucinamide; N-(tert-Butoxycarbonyl)-L-leucinamide; Boc-Leu-NH2; tert-Butyloxycarbonyl-L-leucinamide; L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-, amide; 687-51-4
EINECS	Contact for details

Quality Control

Our H-Leu-Nh2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide comprehensive Certificates of Analysis (COA) to ensure traceability and compliance with customer specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.