Description

H-Leu-Gly-Oh is a high-purity dipeptide derivative, specifically the C-terminal carboxylic acid of the leucine-glycine sequence. This compound serves as a crucial building block and intermediate in advanced organic synthesis and peptide research. It is essential for pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in developing novel therapeutic peptides, enzyme substrates, and biochemical tools.

Application

• Pharmaceutical Intermediate: Key starting material for the synthesis of longer, more complex peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies and proteomics research to investigate enzyme specificity and function.
• Peptide Synthesis: A fundamental building block (amino acid derivative) in solid-phase and solution-phase peptide synthesis (SPPS) for constructing custom peptide sequences.
• Chemical Biology Probes: Incorporation into labeled or modified peptides for studying protein-protein interactions, cell signaling pathways, and diagnostic assays.
• Cosmetic Peptide Precursor: Potential intermediate in the manufacture of bioactive peptides for advanced skincare and cosmetic formulations.

Basic Information

Product Name	H-Leu-Gly-Oh
CAS No.	686-50-0
Molecular Formula	C8H16N2O3
Molecular Weight	188.22 g/mol
Synonyms	L-Leucyl-glycine; Leu-Gly; N-(3-Methylbutyl)glycine; Glycine, N-L-leucyl-; H-Leu-Gly-OH; Leucine-glycine dipeptide; L-Leu-Gly; N-L-Leucylglycine
EINECS	211-693-1

Quality Control

Our H-Leu-Gly-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and identity confirmation via spectroscopic methods. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	-40° to -44° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.