Description

H-Thr-Gly-Oh CAS NO 686-44-2 is a high-purity dipeptide derivative consisting of L-threonine and glycine, featuring a free carboxylic acid terminus. This compound serves as a critical building block and intermediate in advanced organic synthesis, enabling the precise construction of complex peptide structures. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing novel therapeutic peptides and biochemical tools.

Application

• Pharmaceutical Intermediate: Key building block for the solid-phase and solution-phase synthesis of therapeutic peptides and peptidomimetics.
• Biochemical Research: Used as a substrate or standard in enzymatic studies and metabolic pathway investigations.
• Proteomics & Diagnostics: Employed in the development of affinity ligands, enzyme substrates, and diagnostic assay components.
• Cosmetic Peptides: A potential raw material for synthesizing bioactive peptides used in advanced skincare formulations.
• Academic & R&D: Serves as a fundamental reagent for university and institutional research in medicinal chemistry and peptide science.
• Chemical Biology Probes: Integral for creating labeled peptides and molecular probes to study protein-protein interactions.

Basic Information

Product Name	H-Thr-Gly-Oh CAS NO 686-44-2
CAS No.	686-44-2
Molecular Formula	C6H12N2O4
Molecular Weight	176.17 g/mol
Synonyms	L-Threonylglycine; H-L-Thr-Gly-OH; Glycine, L-threonyl-; (2S,3R)-2-[(2-Aminoacetyl)amino]-3-hydroxybutanoic acid; Thr-Gly; TG; Threonine-Glycine dipeptide; NSC 3349
EINECS	Contact for details

Quality Control

Our H-Thr-Gly-Oh is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity, ensuring it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: -25° to -30° (c=1 in H₂O)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.