Description

α-Methyl-L-p-Tyrosine is a synthetic amino acid derivative that acts as a potent and selective inhibitor of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis. This compound is a critical research tool for studying neurotransmitter pathways and their role in neurological and cardiovascular functions. It is primarily utilized by pharmaceutical researchers, academic institutions, and fine chemical manufacturers involved in neuroscience, drug discovery, and the development of biochemical standards.

Application

• Neuroscience Research: Used to deplete catecholamines (dopamine, norepinephrine, epinephrine) in experimental models to study their physiological and behavioral roles.
• Pharmacological Studies: Serves as a reference standard and active compound in the investigation of hypertension, stress responses, and psychiatric disorders.
• Biochemical Pathway Analysis: A key reagent for in vitro and in vivo studies of the tyrosine hydroxylase enzyme and catecholamine synthesis.
• Pharmaceutical Intermediates: Can be used in the synthesis of more complex molecules targeting the adrenergic system.
• Reference Standard: Employed as a high-purity calibrant in analytical methods such as HPLC and LC-MS for quality control and metabolic studies.

Basic Information

Product Name	α-Methyl-L-p-Tyrosine
CAS No.	672-87-7
Molecular Formula	C10H13NO3
Molecular Weight	195.22 g/mol
Synonyms	L-α-Methyl-p-tyrosine; AMT; Metirosine; (2S)-2-Amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid; MK-781; H-44/68; α-MPT; L-α-Methyltyrosine; L-α-Methyl-4-hydroxyphenylalanine
EINECS	211-596-8

Quality Control

Our α-Methyl-L-p-Tyrosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, HPLC), assay (HPLC), and impurity profiling to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	[α]20/D: Specific range provided on COA
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.