Description

4,6-Diamino-2-Trifluoromethylpyrimidine is a high-value heterocyclic building block characterized by its pyrimidine core functionalized with amino and trifluoromethyl groups. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceuticals and agrochemicals, where the trifluoromethyl group is prized for enhancing metabolic stability and bioavailability. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral, anticancer, and kinase inhibitor drugs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyrimidine scaffold.
• Material Science Research: Serves as a building block for creating functional organic materials, such as ligands for catalysis or components in organic electronics.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up.

Basic Information

Product Name	4,6-Diamino-2-Trifluoromethylpyrimidine
CAS No.	672-46-8
Molecular Formula	C5H5F3N4
Molecular Weight	178.12 g/mol
Synonyms	2-Trifluoromethyl-4,6-pyrimidinediamine; 4,6-Diamino-2-(trifluoromethyl)pyrimidine; 2-(Trifluoromethyl)pyrimidine-4,6-diamine; 4,6-Diamino-2-trifluoromethyl-pyrimidine; 4,6-Diamino-2-(trifluoromethyl)-pyrimidine; 672-46-8; α,α,α-Trifluoro-4,6-diamino-2-pyrimidinemethane
EINECS	211-598-6

Quality Control

Our 4,6-Diamino-2-Trifluoromethylpyrimidine is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.