Description

5-Difluoromethyluracil is a fluorinated pyrimidine derivative, a key advanced intermediate in the synthesis of novel pharmaceuticals and agrochemicals. Its value lies in the introduction of the difluoromethyl group, a bioisostere that can significantly enhance the metabolic stability, lipophilicity, and biological activity of target molecules. This compound is essential for R&D and production within the pharmaceutical industry for developing antiviral and anticancer agents, as well as in agricultural science for creating next-generation herbicides and fungicides.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of fluorinated nucleoside analogues and other bioactive molecules targeting viral and oncological diseases.
• Antiviral Drug Development: Used in research and production of potential antiviral agents, where the difluoromethyl modification can improve drug efficacy and pharmacokinetic profiles.
• Anticancer Agent Research: Serves as a precursor in the creation of novel chemotherapeutic compounds that exploit fluorinated uracil scaffolds.
• Agrochemical Synthesis: An important intermediate for developing advanced, high-performance herbicides and fungicides with improved environmental and activity profiles.
• Biochemical Research: Employed in studies investigating enzyme mechanisms, metabolic pathways, and the role of fluorinated biomolecules.
• Organic Synthesis Building Block: Utilized in academic and industrial laboratories for constructing complex, fluorinated heterocyclic compounds.

Basic Information

Product Name	5-Difluoromethyluracil
CAS No.	670-19-9
Molecular Formula	C5H4F2N2O2
Molecular Weight	162.10 g/mol
Synonyms	5-(Difluoromethyl)uracil; 5-(Difluoromethyl)-2,4(1H,3H)-pyrimidinedione; 2,4-Dihydroxy-5-(difluoromethyl)pyrimidine; Uracil, 5-(difluoromethyl)-; NSC 52342; 5-Difluoromethyl-2,4-dihydroxypyrimidine; DFMU
EINECS	Contact for details

Quality Control

Our 5-Difluoromethyluracil is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive applications. We provide comprehensive analytical data, including HPLC purity, identity confirmation (IR, NMR), and impurity profiling. A Certificate of Analysis (COA) is supplied with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong alkalis and incompatible materials. Handle and store in accordance with good laboratory and industrial safety practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.