Description

2,6-Difluoro-4-Nitrophenol is a versatile fluorinated aromatic intermediate of significant importance in advanced organic synthesis. Its unique substitution pattern, featuring both electron-withdrawing nitro and fluoro groups, makes it a critical building block for constructing complex molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting specific enzyme pathways where the fluorine atoms enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, pesticides, and fungicides, where the difluoro-nitrophenol scaffold contributes to potent biological activity.
• Liquid Crystal & OLED Material Research: Serves as a starting material for synthesizing fluorinated aromatic cores used in electronic display technologies and organic light-emitting diodes.
• Dye & Pigment Intermediate: Employed in the production of specialized dyes and pigments, where the nitro and fluoro groups influence color fastness and spectral properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl structures.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D focused on fluorine chemistry, material science, and novel synthetic methodologies.

Basic Information

Product Name	2,6-Difluoro-4-Nitrophenol
CAS No.	658-07-1
Molecular Formula	C6H3F2NO3
Molecular Weight	175.09 g/mol
Synonyms	4-Nitro-2,6-difluorophenol; 2,6-Difluoro-4-nitrophenol; Phenol, 2,6-difluoro-4-nitro-; 2,6-Difluoro-4-nitro-1-hydroxybenzene; 4-Hydroxy-3,5-difluoronitrobenzene; NSC 403119; AI3-52220
EINECS	211-513-9

Quality Control

Every batch of 2,6-Difluoro-4-Nitrophenol is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee consistent quality and traceability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases, reducing agents, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.