Description

3-(Trifluoromethyl)Formanilide is a versatile aromatic amide derivative characterized by a trifluoromethyl substituent, serving as a crucial synthetic intermediate in advanced organic chemistry. Its value lies in providing a reactive aniline derivative that facilitates the introduction of the pharmacologically important trifluoromethyl group into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, where it is used to develop novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethylated aniline moiety to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group contributes to improved efficacy and environmental profile.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials due to its aromatic and electron-withdrawing characteristics.
• Dye and Pigment Manufacturing: Acts as a precursor for synthesizing complex colorants and functional dyes with specific light-fastness and solubility properties.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed reactions, such as Buchwald-Hartwig amination, for constructing complex nitrogen-containing heterocycles.

Basic Information

Product Name	3-(Trifluoromethyl)Formanilide
CAS No.	657-78-3
Molecular Formula	C8H6F3NO
Molecular Weight	189.14 g/mol
Synonyms	N-Formyl-3-(trifluoromethyl)aniline; 3-(Trifluoromethyl)phenylformamide; 3-Trifluoromethylformanilide; m-Trifluoromethylformanilide; N-(3-Trifluoromethylphenyl)formamide; Formanilide, 3-(trifluoromethyl)-; 3-Trifluoromethyl-N-formylaniline; 3-Aminobenzotrifluoride formyl derivative
EINECS	211-514-5

Quality Control

Our 3-(Trifluoromethyl)Formanilide is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in GMP-compliant synthesis and other regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	78 - 82 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.