Description

n-Formyl 2-Chloro-5-(Trifluoromethyl)Aniline, also known as n-[2-Chloro-5-(Trifluoromethyl)Phenyl]Formamide, is a high-value, halogenated aniline derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring both chloro and trifluoromethyl substituents, makes it an essential building block for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate for producing complex, high-performance dyes and pigments with specific color fastness and light stability properties.
• Cross-Coupling Reactions: An important substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing biaryl systems common in many advanced molecules.
• Custom Synthesis and Contract Manufacturing: Supplied to fine chemical companies and CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.

Basic Information

Product Name	n-Formyl 2-Chloro-5-(Trifluoromethyl)Aniline
CAS No.	657-63-6
Molecular Formula	C8H5ClF3NO
Molecular Weight	223.58 g/mol
Synonyms	2-Chloro-α,α,α-trifluoro-p-formotoluidide; N-(2-Chloro-5-(trifluoromethyl)phenyl)formamide; 2-Chloro-5-(trifluoromethyl)formanilide; Formamide, N-[2-chloro-5-(trifluoromethyl)phenyl]-; 2-Chloro-α,α,α-trifluoro-p-formotoluidid; N-Formyl-2-chloro-5-(trifluoromethyl)aniline; 2-Chloro-5-trifluoromethylformanilide
EINECS	211-502-5

Quality Control

Every batch of n-Formyl 2-Chloro-5-(Trifluoromethyl)Aniline is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure consistency and purity. Our standard grade typically meets a purity specification of ≥98.0% (by HPLC), with stringent controls on key impurities. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with each shipment. We can also supply material tailored to meet specific customer requirements, including higher purity grades for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to minimize exposure to atmospheric moisture. Store away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.