Description

2-Chloro-6-Trifluoromethyl-Pyrimidine-4-Carboxylic Acid is a high-value, multi-functional heterocyclic building block essential for advanced chemical synthesis. Its core value lies in the strategic combination of a reactive chloro substituent, a stable trifluoromethyl group, and a versatile carboxylic acid moiety, enabling precise molecular construction. This compound is critically needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral, anticancer, and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Serves as a core scaffold for developing new-generation herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing trifluoromethyl group.
• Material Science Research: Used in the development of advanced organic materials, including liquid crystals and polymers with specific electronic properties.
• Chemical Biology Probes: Employed in medicinal chemistry for creating tool compounds and probes to study biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-Chloro-6-Trifluoromethyl-Pyrimidine-4-Carboxylic Acid
CAS No.	657-53-4
Molecular Formula	C6H2ClF3N2O2
Molecular Weight	226.54 g/mol
Synonyms	2-Chloro-6-(trifluoromethyl)pyrimidine-4-carboxylic acid; 4-Pyrimidinecarboxylic acid, 2-chloro-6-(trifluoromethyl)-; 2-Chloro-6-trifluoromethylpyrimidine-4-carboxylic acid; 6-Trifluoromethyl-2-chloropyrimidine-4-carboxylic acid; 2-Chloro-4-carboxy-6-trifluoromethylpyrimidine; 657-53-4; 2-Chloro-6-trifluoromethyl-4-pyrimidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Trifluoromethyl-Pyrimidine-4-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.