Description

3,5-Difluoro-4-Methoxybenzaldehyde is a versatile fluorinated aromatic aldehyde building block of significant importance in advanced organic synthesis. Its unique substitution pattern, featuring two fluorine atoms and a methoxy group, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, where it is used to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting central nervous system (CNS) disorders, anti-inflammatory agents, and oncology treatments.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity, metabolic stability, and lipophilicity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated mesogens and electron-transport materials, contributing to improved performance and stability in display and lighting technologies.
• Polymer & Specialty Chemicals: Acts as a monomer or modifier in the production of high-performance polymers, coatings, and adhesives with enhanced chemical resistance and thermal properties.
• Cross-Coupling Reactions: The aldehyde group is a versatile handle for further functionalization via reactions like Suzuki, Heck, or reductive amination, enabling rapid library synthesis for drug discovery.
• Fluorinated Dye & Pigment Precursor: Employed in the synthesis of specialized dyes and pigments where fluorine substitution alters light absorption and color fastness.

Basic Information

Product Name	3,5-Difluoro-4-Methoxybenzaldehyde
CAS No.	654-11-5
Molecular Formula	C8H6F2O2
Molecular Weight	172.13 g/mol
Synonyms	4-Methoxy-3,5-difluorobenzaldehyde; 3,5-Difluoro-4-methoxybenzaldehyde; 3,5-Difluoro-p-anisaldehyde; 654-11-5; 4-Methoxy-3,5-difluorobenzenecarboxaldehyde; Benzaldehyde, 3,5-difluoro-4-methoxy-; Difluoro Methoxy Benzaldehyde
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-Methoxybenzaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is easily oxidized; for long-term storage, consider keeping under an inert atmosphere such as nitrogen or argon. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.