Description

Pentafluorobenzaldehyde CAS NO 653-37-2 is a highly fluorinated aromatic aldehyde characterized by its five fluorine substituents on the benzene ring. This unique structure makes it a versatile and valuable building block in advanced organic synthesis, particularly for introducing the pentafluorophenyl moiety. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science sectors who require high-purity intermediates for developing active ingredients, ligands, and specialty polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds requiring the pentafluorophenyl group to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the production of fluorinated polymers, liquid crystals, and electronic materials to impart specific chemical resistance and physical properties.
• Chemical Research: A fundamental reagent in organic chemistry for nucleophilic addition reactions, reductive amination, and as a scaffold for heterocycle formation.
• Derivatization Agent: Used in analytical chemistry for derivatizing compounds to improve their detection in chromatographic methods like HPLC and GC.

Basic Information

Product Name	Pentafluorobenzaldehyde
CAS No.	653-37-2
Molecular Formula	C7HF5O
Molecular Weight	196.08 g/mol
Synonyms	2,3,4,5,6-Pentafluorobenzaldehyde; Perfluorobenzaldehyde; Pentafluorobenzenecarboxaldehyde; Benzaldehyde, 2,3,4,5,6-pentafluoro-; Pentafluorophenyl aldehyde; Pentafluorobenzene-1-carbaldehyde; Pentafluorobenzaldehyde (PFBA); 2,3,4,5,6-Pentafluorobenzaldehyde
EINECS	211-485-5

Quality Control

Our Pentafluorobenzaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency that meets the stringent requirements of fine chemical and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. This material is easily oxidized; ensure containers are sealed properly after each use to minimize exposure to air.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.