Description

L-Histidine Hydrochloride is the hydrochloride salt of the essential amino acid L-Histidine, a critical building block for proteins and enzymes. This high-purity compound is vital for applications requiring precise biochemical activity and stability. It is primarily utilized by manufacturers in the pharmaceutical, nutraceutical, and research sectors for formulating parenteral nutrition, dietary supplements, and cell culture media.

Application

• Pharmaceutical Intermediates: A key raw material in the synthesis of active pharmaceutical ingredients (APIs) and infusion solutions.
• Parenteral & Enteral Nutrition: An essential component in amino acid formulations for clinical nutrition and critical care.
• Dietary Supplements & Sports Nutrition: Used in protein powders, amino acid blends, and performance-enhancing supplements.
• Biochemical Research & Cell Culture: Serves as a nutrient in microbiological media and cell culture applications for life science research.
• Food & Beverage Fortification: Employed as a nutritional enhancer in specialized food products and functional beverages.
• Cosmetic & Personal Care: Incorporated into skincare formulations for its purported moisturizing and skin-conditioning properties.

Basic Information

Product Name	L-Histidine Hydrochloride
CAS No.	645-35-2
Molecular Formula	C6H9N3O2 • HCl
Molecular Weight	191.62 g/mol
Synonyms	L-Histidine HCl; L-Histidine Monohydrochloride; (S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid hydrochloride; Histidine hydrochloride; H-His-OH • HCl; Histidine HCl; L-Histidine hydrochloride monohydrate (common hydrate form); Histidinium chloride
EINECS	211-438-9

Quality Control

Our L-Histidine Hydrochloride is manufactured under strict quality management systems. It undergoes rigorous analytical testing to ensure compliance with relevant pharmacopoeial standards such as USP, EP, and JP, as well as food-grade specifications like FCC. A comprehensive Certificate of Analysis (COA), detailing purity, identity, and impurity profiles, is provided with each batch to guarantee traceability and consistency for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Specific Rotation	+8.5° to +10.5° (c=2 in 6N HCl)
pH (5% solution)	3.0 - 5.0
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.