Description

2-Hydroxyglutaric Acid is a dicarboxylic acid derivative that serves as a key chiral building block and metabolic intermediate. This compound matters for its role in biochemical research and as a precursor in the synthesis of fine chemicals and active pharmaceutical ingredients (APIs). Industries that need it include pharmaceutical development, academic research, and specialty chemical manufacturing for producing high-value intermediates. Its unique structure offers versatility in organic synthesis and metabolic pathway studies.

Application

• Pharmaceutical intermediate for the synthesis of chiral drugs and active pharmaceutical ingredients (APIs).
• Biochemical research reagent for studying metabolic disorders, particularly those related to glutaric acidurias.
• Chiral building block in asymmetric synthesis for producing enantiomerically pure compounds.
• Precursor for manufacturing specialty polymers and fine chemicals with specific functional groups.
• Reference standard in analytical chemistry for method development and quality control in pharmaceutical and diagnostic labs.
• Substrate for enzymatic studies and metabolic pathway analysis in cell biology and biochemistry.

Basic Information

Product Name	2-Hydroxyglutaric Acid
CAS No.	636-67-9
Molecular Formula	C5H8O5
Molecular Weight	148.11 g/mol
Synonyms	2-Hydroxypentanedioic Acid; α-Hydroxyglutaric Acid; 2-Hydroxy-1,5-pentanedioic Acid; (RS)-2-Hydroxyglutaric Acid; DL-2-Hydroxyglutaric Acid; Hydroxyglutaric Acid; 2-Hydroxyglutamate; 636-67-9 (CAS)
EINECS	211-279-5

Quality Control

Our 2-Hydroxyglutaric Acid undergoes rigorous quality testing to ensure compliance with industry standards for purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, chiral purity, and impurity profiles. Our quality management system adheres to cGMP principles where applicable, supporting its use in research and development as well as non-GMP pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed to prevent absorption of atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	Contact for details
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.