Description

3-Nitro-L-Tyrosine is a chemically modified derivative of the essential amino acid L-tyrosine, featuring a nitro group substitution. This modification makes it a valuable biochemical tool and a key intermediate in the synthesis of more complex molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in biochemical research, proteomics, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving tyrosine kinases, phosphatases, and nitric oxide synthase.
• Proteomics & Protein Labeling: Serves as a precursor for introducing nitrotyrosine residues into peptides and proteins to study oxidative stress, post-translational modifications, and protein function.
• Pharmaceutical Intermediate: Acts as a key building block in the synthesis of potential drug candidates and diagnostic agents targeting neurological and inflammatory pathways.
• Reference Standard: Employed as an analytical standard in HPLC, LC-MS, and other chromatographic methods for the quantification of nitrotyrosine in biological samples.
• Antioxidant & Nitric Oxide Research: Utilized in studies investigating reactive nitrogen species, peroxynitrite formation, and cellular oxidative damage.

Basic Information

Product Name	3-Nitro-L-Tyrosine
CAS No.	621-44-3
Molecular Formula	C9H10N2O5
Molecular Weight	226.19 g/mol
Synonyms	L-3-Nitrotyrosine; (2S)-2-Amino-3-(4-hydroxy-3-nitrophenyl)propanoic acid; 3-Nitro-L-tyrosine; 3-NT; NO2-Tyr; 3-Nitrotyrosine; Tyr(NO2)
EINECS	210-694-5

Quality Control

Our 3-Nitro-L-Tyrosine is produced under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	-10.0° to -12.0° (c=1 in 1N HCl)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.