Description

2-Chloro-4-Hydroxyquinazoline is a versatile heterocyclic building block of significant importance in advanced organic synthesis. Its core quinazoline scaffold, functionalized with chloro and hydroxy groups, makes it a critical intermediate for constructing complex molecules with targeted biological activity. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel drug candidates and active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various quinazoline-based therapeutic agents, including kinase inhibitors and other small-molecule drugs.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides that leverage the bioactive quinazoline structure.
• Organic Synthesis Building Block: Serves as a versatile scaffold for constructing complex heterocyclic compounds in medicinal and process chemistry.
• Research & Development: Employed in academic and industrial R&D settings for exploring new chemical entities and structure-activity relationships.
• Material Science: Potential use as an intermediate for the synthesis of specialty chemicals and functional materials.

Basic Information

Product Name	2-Chloro-4-Hydroxyquinazoline
CAS No.	607-69-2
Molecular Formula	C8H5ClN2O
Molecular Weight	180.59 g/mol
Synonyms	4-Hydroxy-2-chloroquinazoline; 2-Chloro-4-quinazolinol; 2-Chloro-4(3H)-quinazolinone; 2-Chloro-4-oxo-3,4-dihydroquinazoline; 4(1H)-Quinazolinone, 2-chloro-; 2-Chlor-4-hydroxy-chinazolin (German); 2-クロロ-4-ヒドロキシキナゾリン (Japanese)
EINECS	210-138-2

Quality Control

Our 2-Chloro-4-Hydroxyquinazoline is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.