Description

Thiocolchicoside is a semi-synthetic derivative of colchicoside, belonging to the class of thiocolchicine glycosides. This compound is valued for its potent muscle relaxant and anti-inflammatory properties, making it a critical active pharmaceutical ingredient (API). It is primarily required by pharmaceutical manufacturers for the formulation of prescription medications targeting musculoskeletal disorders, including muscle spasms and associated pain.

Application

• Pharmaceutical API: Core active ingredient in prescription muscle relaxant and anti-inflammatory injectable and oral formulations.
• Muscle Spasm Treatment: Used in medications for the management of acute, painful muscle spasms and contractures.
• Orthopedic & Rheumatologic Therapies: Incorporated into treatments for conditions like low back pain, cervical syndrome, and post-traumatic recovery.
• Neuromuscular Research: Serves as a reference standard and tool compound in pharmacological studies of GABAergic and glycine receptor modulation.
• Generic Drug Manufacturing: Essential for the production of generic versions of established thiocolchicoside-based medicines for global markets.
• Veterinary Pharmaceuticals: Potential application in veterinary medicine for treating musculoskeletal issues in animals.

Basic Information

Product Name	Thiocolchicoside
CAS No.	602-41-5
Molecular Formula	C27H33NO9S
Molecular Weight	547.62 g/mol
Synonyms	Thiocolchicoside; Muscoril; Myoril; Colchicoside thiomethyl ether; 3-Demethylthiocolchicine; (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide; 2,3,4,9-Tetramethoxy-10-(methylthio)-6,7-dihydro-5H-tropolobenzene-7-carboxamide; NSC-361792
EINECS	Contact for details

Quality Control

Our Thiocolchicoside is manufactured under strict quality systems to meet the rigorous standards of the pharmaceutical industry. We provide material that complies with relevant pharmacopeial monographs (e.g., EP, USP) and is supported by a comprehensive Certificate of Analysis (COA). Each batch is tested for identity, purity, potency, and specified impurities to ensure reliable performance and regulatory compliance for your formulations.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Specific Optical Rotation	-185° to -195° (c=1 in chloroform)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.