Description

Dicumarol is a naturally occurring coumarin derivative and a potent vitamin K antagonist, widely recognized for its anticoagulant properties. This compound is critical for research and development in the pharmaceutical and life sciences sectors, serving as a key reference standard and active pharmaceutical ingredient (API) intermediate. It is primarily utilized by manufacturers and research institutions focused on hematology, biochemistry, and the development of therapeutic agents for thrombotic disorders.

Application

• Pharmaceutical Research & Development: Used as a reference standard and biochemical tool in the study of blood coagulation mechanisms and vitamin K metabolism.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key precursor in the synthesis of anticoagulant medications and related therapeutic compounds.
• Biochemical Assays: Employed in in vitro studies to inhibit vitamin K epoxide reductase, facilitating research on clotting factors and metabolic pathways.
• Veterinary Medicine: Investigated for applications in veterinary anticoagulant therapies and rodenticide formulations.
• Academic & Industrial Research: A fundamental compound for universities and contract research organizations (CROs) conducting pharmacological and toxicological studies.

Basic Information

Product Name	Dicumarol
CAS No.	66-76-2
Molecular Formula	C19H12O6
Molecular Weight	336.29 g/mol
Synonyms	3,3'-Methylenebis(4-hydroxycoumarin); Bishydroxycoumarin; Dicoumarin; Dicoumarol; Melitoxin; Dufalone; Antithrombosin; Cumid; Dicoumarin; 3,3'-Methylenebis(4-hydroxy-2H-chromen-2-one)
EINECS	200-627-5

Quality Control

Our Dicumarol is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC chromatograms and impurity profiles, to support your research and regulatory requirements. Certificates of Analysis (COA) are available for every batch upon request, detailing compliance with in-house specifications suitable for research and pharmaceutical intermediate use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.