Description

2,3,4,5,6-Pentafluorophenyl 1-Ethanesulfonate is a high-value organofluorine building block and sulfonate ester reagent. This compound is essential for introducing the pentafluorophenylsulfonyl (Pfp) group, a versatile protecting and activating moiety in synthetic organic chemistry. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing sulfonate ester groups in nucleoside and peptide chemistry.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that incorporate fluorinated aromatic systems for enhanced activity and stability.
• Protecting Group Chemistry: Serves as a precursor for generating pentafluorophenylsulfonyl (Pfp) protecting groups for alcohols and amines in multi-step organic synthesis.
• Material Science: Building block for creating fluorinated polymers, liquid crystals, and other advanced materials with unique surface properties and chemical resistance.
• Cross-Coupling Reactions: Acts as an electrophile in palladium-catalyzed cross-coupling reactions to form carbon-carbon and carbon-heteroatom bonds.
• Bioconjugation: Useful in modifying biomolecules, such as proteins and peptides, for labeling and probe development due to its reactivity with nucleophiles.

Basic Information

Product Name	2,3,4,5,6-Pentafluorophenyl 1-Ethanesulfonate
CAS No.	597553-60-1
Molecular Formula	C8H5F5O3S
Molecular Weight	276.18 g/mol
Synonyms	Pentafluorophenyl ethanesulfonate; Ethanesulfonic acid pentafluorophenyl ester; 2,3,4,5,6-Pentafluorophenyl ethanesulfonate; PFP-ES; Pentafluorophenylsulfonyl ethyl ester; 1-(Pentafluorophenyl)ethyl sulfonate; Pentafluorophenyl ethyl sulfonate
EINECS	Contact for details

Quality Control

Our 2,3,4,5,6-Pentafluorophenyl 1-Ethanesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting cGMP and ISO standards for traceability and reliability in research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.