Description

[1-(6-Chloro-Pyrimidin-4-Yl)-Piperidin-4-Yl]-Carbamic Acid tert-Butyl Ester is a high-purity (98+%) chemical intermediate with the molecular formula C14H21ClN4O2 and a molecular weight of 312.8. This compound is a critical building block in modern pharmaceutical synthesis, valued for its piperidine-pyrimidine core structure which is a privileged scaffold in medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates, especially kinase inhibitors and receptor modulators.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize lead compounds.
• API Development: Integral to the scalable synthesis route for Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Chemical Biology Probes: Employed in the creation of tool compounds for target validation and pathway analysis in biological systems.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke molecules for clients.
• Agrochemical Research: Potential application in the development of new agrochemicals due to its heterocyclic structure.

Basic Information

Product Name	[1-(6-Chloro-Pyrimidin-4-Yl)-Piperidin-4-Yl]-Carbamic Acid tert-Butyl Ester
CAS No.	596817-50-4
Molecular Formula	C14H21ClN4O2
Molecular Weight	312.80 g/mol
Synonyms	tert-Butyl N-[1-(6-chloropyrimidin-4-yl)piperidin-4-yl]carbamate; 1-(6-Chloro-4-pyrimidinyl)-4-piperidinecarboxylic acid 1,1-dimethylethyl ester; 4-[[(1,1-Dimethylethoxy)carbonyl]amino]-1-(6-chloro-4-pyrimidinyl)piperidine; BOC-Piperidine-Pyrimidine Chloride Intermediate; 4-(N-Boc-amino)-1-(6-chloropyrimidin-4-yl)piperidine; 596817-50-4; 1-(6-Chloro-pyrimidin-4-yl)-piperidin-4-yl-carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our [1-(6-Chloro-Pyrimidin-4-Yl)-Piperidin-4-Yl]-Carbamic Acid tert-Butyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC assay, residual solvent analysis (GC), and identity confirmation (NMR, IR, MS). A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent specifications. We support development from research to commercial scale with quality standards suitable for GMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from degradation. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.