Description

2-Pyrimidinecarboxamide,n-(3R)-1-Azabicyclo[3.2.2]Non-3-Yl-(9Ci) is a high-purity, advanced pharmaceutical intermediate characterized by its complex, chiral bicyclic structure. This compound is of significant commercial importance for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in neurological and receptor-targeted therapeutic areas. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new chemical entities (NCEs).

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug candidates targeting the central nervous system.
• Neurological Research: Used in the development of ligands and modulators for nicotinic acetylcholine receptors (nAChRs) and other neurological targets.
• Medicinal Chemistry: Serves as a critical scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Development: Employed in the scale-up and optimization of synthetic routes for GMP (Good Manufacturing Practice) production of APIs.
• Contract Manufacturing: Supplied to CDMOs for the custom synthesis of proprietary compounds for clinical trial materials.

Basic Information

Product Name	2-Pyrimidinecarboxamide,n-(3R)-1-Azabicyclo[3.2.2]Non-3-Yl-(9Ci)
CAS No.	590372-22-8
Molecular Formula	C13H18N4O
Molecular Weight	246.31 g/mol
Synonyms	(3R)-N-(1-Azabicyclo[3.2.2]non-3-yl)pyrimidine-2-carboxamide; (R)-N-(1-Azabicyclo[3.2.2]non-3-yl)pyrimidine-2-carboxamide; 2-Pyrimidinecarboxamide, N-[(3R)-1-azabicyclo[3.2.2]non-3-yl]-; UNII-8F7Y8K9Q0F; 590372-22-8; (R)-N-(1-Azabicyclo[3.2.2]nonan-3-yl)pyrimidine-2-carboxamide; (3R)-1-Azabicyclo[3.2.2]non-3-amine, N-(2-pyrimidinylcarbonyl)-
EINECS	Contact for details

Quality Control

Our production of 2-Pyrimidinecarboxamide,n-(3R)-1-Azabicyclo[3.2.2]Non-3-Yl-(9Ci) adheres to stringent quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development use. All materials are characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.