Description

Pyrrolo[1,2-C]Pyrimidine-3-Carboxamide, n-(1S,2R,4R)-7-Azabicyclo[2.2.1]Hept- is a high-purity, advanced pharmaceutical intermediate characterized by its complex, stereochemically defined bicyclic structure. This compound is of significant commercial value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high selectivity. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of next-generation small molecule drugs, including potential candidates for neurological and oncological applications.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting G-protein-coupled receptors (GPCRs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and pharmacokinetic profiles.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high stereochemical purity.
• Academic Research: Utilized in university and institutional labs for studying novel heterocyclic chemistry and developing new synthetic methodologies.

Basic Information

Product Name	Pyrrolo[1,2-C]Pyrimidine-3-Carboxamide, n-(1S,2R,4R)-7-Azabicyclo[2.2.1]Hept-
CAS No.	588726-81-2
Molecular Formula	C12H16N4O
Molecular Weight	232.28 g/mol
Synonyms	N-[(1S,2R,4R)-7-Azabicyclo[2.2.1]hept-2-yl]pyrrolo[1,2-c]pyrimidine-3-carboxamide; (1S,2R,4R)-N-(7-Azabicyclo[2.2.1]hept-2-yl)pyrrolo[1,2-c]pyrimidine-3-carboxamide; 7-Azabicyclo[2.2.1]heptane-2-carboxamide, N-(pyrrolo[1,2-c]pyrimidin-3-yl)-, (1S,2R,4R)-; Pyrrolopyrimidine carboxamide derivative; Bicyclic pyrrolopyrimidine intermediate; Stereoisomer of pharmaceutical intermediate 588726-81-2
EINECS	Contact for details

Quality Control

Every batch of Pyrrolo[1,2-C]Pyrimidine-3-Carboxamide is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and stereochemical purity essential for pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.