Description

2(1H)-Pyrimidinone,4-Amino-5-Fluoro-1-(5S)-5-Isoxazolidinyl-(9Ci) is a high-purity, fluorinated pyrimidinone derivative with a chiral isoxazolidinyl substituent, representing a sophisticated building block for advanced chemical synthesis. Its primary value lies in its role as a key intermediate in the research and development of novel pharmaceutical compounds, particularly those targeting specific enzymatic pathways. This compound is essential for medicinal chemistry researchers and process development scientists in the pharmaceutical and biotechnology industries who require structurally complex, optically active intermediates for drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of potential active pharmaceutical ingredients (APIs), especially for antiviral or anticancer agents.
• Medicinal Chemistry Research: Used as a scaffold or precursor in structure-activity relationship (SAR) studies to explore new chemical entities with therapeutic potential.
• Process Chemistry Development: Employed in the optimization and scale-up of synthetic routes for complex molecules during preclinical and clinical development phases.
• Biochemical Probe Synthesis: Utilized to create labeled or modified compounds for investigating biological mechanisms and target engagement.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the life sciences sector.

Basic Information

Product Name	2(1H)-Pyrimidinone,4-Amino-5-Fluoro-1-(5S)-5-Isoxazolidinyl-(9Ci)
CAS No.	588715-98-4
Molecular Formula	C7H9FN4O2
Molecular Weight	200.17 g/mol
Synonyms	4-Amino-5-fluoro-1-[(5S)-1,2-oxazolidin-5-yl]pyrimidin-2(1H)-one; 4-Amino-5-fluoro-1-((5S)-isoxazolidin-5-yl)pyrimidin-2(1H)-one; (5S)-5-(4-Amino-5-fluoro-2-oxo-1,2-dihydropyrimidin-1-yl)-1,2-oxazolidine; 4-Amino-5-fluoro-1-(5S-isoxazolidinyl)-2(1H)-pyrimidinone; Fluorinated Pyrimidinone Isoxazolidine Derivative; Chiral Isoxazolidinyl Pyrimidinone Intermediate
EINECS	Contact for details

Quality Control

Our production of 2(1H)-Pyrimidinone,4-Amino-5-Fluoro-1-(5S)-5-Isoxazolidinyl-(9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. All material is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity, chiral purity, and impurity profiles. Certificates of Analysis (COA) detailing specific results are provided with each shipment, and we support compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere to prevent degradation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.