Description

2(1H)-Pyrimidinone,4-Amino-5-Fluoro-1-(5R)-5-Isoxazolidinyl-(9Ci) is a high-purity, fluorinated pyrimidinone derivative with a chiral isoxazolidinyl substituent, representing a sophisticated building block in advanced organic synthesis. Its core value lies in its precise molecular architecture, which is critical for imparting specific biological activity and physicochemical properties in target molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for antiviral and anticancer therapies, where its unique scaffold serves as a key intermediate.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of novel nucleoside analog prodrugs and other potential therapeutic agents.
• Antiviral Drug Research: Used in the research and development of next-generation antiviral compounds, leveraging its fluorinated pyrimidine core.
• Oncology Research: Employed as a key synthetic precursor in the discovery of targeted cancer therapies and kinase inhibitors.
• Chemical Biology & Proteomics: Acts as a specialized scaffold or probe in studying enzyme mechanisms and protein-ligand interactions.
• Process Chemistry & Scale-Up: Utilized in route scouting and optimization for the commercial-scale production of complex active pharmaceutical ingredients (APIs).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific advanced intermediates.

Basic Information

Product Name	2(1H)-Pyrimidinone,4-Amino-5-Fluoro-1-(5R)-5-Isoxazolidinyl-(9Ci)
CAS No.	588715-97-3
Molecular Formula	C7H9FN4O2
Molecular Weight	200.17 g/mol
Synonyms	4-Amino-5-fluoro-1-[(5R)-1,2-oxazolidin-5-yl]pyrimidin-2(1H)-one; 4-Amino-5-fluoro-1-((5R)-isoxazolidin-5-yl)pyrimidin-2(1H)-one; (5R)-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,2-oxazolidine; A key intermediate for GS-7340 (Tenofovir Alafenamide); TAF Intermediate; 588715-97-3; 4-Amino-1-((5R)-1,2-oxazolidin-5-yl)-5-fluoropyrimidin-2(1H)-one
EINECS	Contact for details

Quality Control

Every batch of our 2(1H)-Pyrimidinone,4-Amino-5-Fluoro-1-(5R)-5-Isoxazolidinyl-(9Ci) is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical research and development. Our quality protocols are designed to support regulatory filings, with a focus on chiral purity, chemical identity, and impurity profile control. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), chiral purity, and related substances is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (5R isomer)
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.