Description

Fmoc-Lys(Boc-Cys(Trt))-OH is a sophisticated, orthogonally protected amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over side-chain reactivity during the construction of complex peptides and peptidomimetics. It is primarily utilized by pharmaceutical R&D teams, biotech companies, and CROs engaged in the development of therapeutic peptides, diagnostic probes, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled, sequential assembly of peptides, particularly those containing lysine and cysteine residues.
• Therapeutic Peptide Development: Enables the synthesis of peptide candidates for oncology, metabolic disorders, and infectious diseases where specific side-chain protection is required.
• Peptidomimetic & Conjugate Synthesis: Used to create modified peptides or peptide-drug conjugates (PDCs) with tailored properties for enhanced stability and bioavailability.
• Biochemical Research & Probe Design: Essential for producing labeled or tagged peptides used in enzyme studies, receptor binding assays, and cellular imaging.
• Antibody-Drug Conjugate (ADC) Linker Chemistry: Serves as a precursor for constructing specialized linkers that connect cytotoxic payloads to antibodies.
• Combinatorial Library Generation: A valuable component for creating diverse peptide libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	Fmoc-Lys(Boc-Cys(Trt))-OH
CAS No.	587854-43-1
Molecular Formula	C46H48N4O7S
Molecular Weight	801.0 g/mol
Synonyms	Fmoc-Lys(Boc-Cys(Trt))-OH; Nα-Fmoc-Nε-Boc-Nγ-Trt-L-lysyl-L-cysteine; Fmoc-Lys(Boc-Cys(Trt))-OH CAS 587854-43-1; Fmoc-Lys(Boc-Cys(Trt))-OH; Fmoc-Lys(Boc-Cys(Trt)); Nα-(9-Fluorenylmethoxycarbonyl)-Nε-(tert-butoxycarbonyl)-Nγ-(trityl)-L-lysyl-L-cysteine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((S)-3-((tert-butoxycarbonyl)amino)-2-(tritylamino)-3-oxopropyl)amino)-6-oxohexanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Lys(Boc-Cys(Trt))-OH is manufactured under strict quality systems to ensure the high purity and consistency required for sensitive synthetic applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to industry best practices, and specifications can be aligned with cGMP guidelines for advanced pharmaceutical development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.