Description

N⁴-(3-Fluorophenyl)-N²-(4-Methoxyphenyl)-5-Nitropyrimidine-2,4,6-Triamine is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is critical for the research and development of novel therapeutic agents, particularly in the fields of oncology and targeted drug discovery. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel small-molecule drug candidates, particularly kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Oncology Drug Development: A potential precursor in the synthesis of targeted anti-cancer agents due to its pyrimidine-triamine scaffold.
• Chemical Biology Probes: Employed in the development of chemical probes for studying specific biological pathways and protein functions.
• Process Chemistry & Scale-Up: Used in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Academic & Institutional Research: A valuable reagent for universities and research institutes exploring new heterocyclic chemistry and drug discovery methodologies.

Basic Information

Product Name	N⁴-(3-Fluorophenyl)-N²-(4-Methoxyphenyl)-5-Nitropyrimidine-2,4,6-Triamine
CAS No.	586985-21-9
Molecular Formula	C₁₇H₁₅FN₆O₃
Molecular Weight	370.34 g/mol
Synonyms	5-Nitro-N⁴-(3-fluorophenyl)-N²-(4-methoxyphenyl)-2,4,6-pyrimidinetriamine; 2,4,6-Triamino-5-nitro-N⁴-(3-fluorophenyl)-N²-(4-methoxyphenyl)pyrimidine; N2-(4-Methoxyphenyl)-N4-(3-fluorophenyl)-5-nitropyrimidine-2,4,6-triamine; 586985-21-9; 5-Nitropyrimidine-2,4,6-triamine, N⁴-(3-fluorophenyl)-N²-(4-methoxyphenyl)-; 3-Fluoro-N2-(4-methoxyphenyl)-5-nitropyrimidine-2,4,6-triamine
EINECS	Contact for details

Quality Control

Our N⁴-(3-Fluorophenyl)-N²-(4-Methoxyphenyl)-5-Nitropyrimidine-2,4,6-Triamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material meets the stringent requirements for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.