Description

(D-Pro7)-Angiotensin I/II (1-7) CAS NO 586962-44-9 is a synthetic, modified peptide analog of the endogenous angiotensin peptide fragments, designed with a D-proline substitution at position 7 to enhance its metabolic stability and receptor selectivity. This engineered modification is critical for research applications requiring prolonged biological activity and resistance to enzymatic degradation. It serves as a valuable biochemical tool for researchers and developers in pharmaceutical R&D, cardiovascular research, and biochemical assay development, facilitating studies on the renin-angiotensin system and related therapeutic pathways.

Application

• Biomedical Research: Used as a stable reference standard or active agent in studies investigating the renin-angiotensin system (RAS), blood pressure regulation, and tissue remodeling.
• Pharmacological Studies: Employed in receptor binding assays, signal transduction research, and functional characterization of angiotensin receptor subtypes (e.g., AT1, AT2, MAS1).
• Drug Discovery & Development: Serves as a key intermediate or biochemical tool in the design and screening of novel cardiovascular and metabolic disease therapeutics.
• Diagnostic Development: Utilized in the development and calibration of immunoassays (e.g., ELISA) for detecting angiotensin peptide levels in biological samples.
• Academic Research: A critical reagent for university and institutional labs focusing on peptide chemistry, hormone action, and molecular pharmacology.
• Biotech & CROs: Supplied to contract research organizations and biotechnology companies for client projects requiring high-purity, well-characterized peptide actives.

Basic Information

Product Name	(D-Pro7)-Angiotensin I/II (1-7)
CAS No.	586962-44-9
Molecular Formula	C41H62N12O10
Molecular Weight	882.99 g/mol
Synonyms	Angiotensin I/II (1-7) (D-Pro7); [D-Pro7]-Angiotensin I/II (1-7); Asp-Arg-Val-Tyr-Ile-His-D-Pro; DRVYIHD-Pro; (D-Proline-7)-Angiotensin (1-7); Angiotensin (1-7) D-Pro7 analog; Modified Angiotensin Fragment
EINECS	Contact for details

Quality Control

Every batch of (D-Pro7)-Angiotensin I/II (1-7) is manufactured and analyzed under stringent quality management systems. Our products undergo rigorous quality testing, including HPLC for purity verification, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA), to ensure compliance with research-grade standards. Comprehensive Certificates of Analysis (COA) detailing purity, peptide content, and analytical results are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.