Description

5-Pyrimidinecarbonyl Chloride, 1,2-Dihydro-4-Methyl-2-Oxo- (9Ci) is a high-value, reactive heterocyclic building block primarily used in advanced organic synthesis. This compound is critical for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals due to its versatile pyrimidine core. It is an essential intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Serves as a precursor for specialty chemicals, dyes, and functional materials.
• Academic & Contract Research: Enables medicinal chemistry research and structure-activity relationship (SAR) studies in R&D laboratories.
• Peptide Mimetics: Used to incorporate heterocyclic motifs into peptide backbones for creating bioactive compounds.
• Material Science: Potential monomer or cross-linking agent for creating polymers with specific electronic or photonic properties.

Basic Information

Product Name	5-Pyrimidinecarbonyl Chloride, 1,2-Dihydro-4-Methyl-2-Oxo- (9Ci)
CAS No.	583883-61-8
Molecular Formula	C6H5ClN2O2
Molecular Weight	172.57 g/mol
Synonyms	4-Methyl-2-oxo-1,2-dihydropyrimidine-5-carbonyl chloride; 1,2-Dihydro-4-methyl-2-oxopyrimidine-5-carbonyl chloride; 5-Carboxy-4-methyl-2(1H)-pyrimidinone chloride; 4-Methyl-2-oxo-1,2-dihydro-5-pyrimidinecarbonyl chloride; 5-(Chlorocarbonyl)-4-methyl-2(1H)-pyrimidinone
EINECS	Contact for details

Quality Control

Our 5-Pyrimidinecarbonyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support customer audits and provide material traceability to meet the stringent requirements of cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases, oxidizing agents, and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.