Description

2,3-Difluoro-4-(trifluoromethyl)benzylamine is a high-value, multi-fluorinated aromatic amine building block. This compound is critical for introducing specific fluorine-substituted benzyl motifs into target molecules, which can dramatically alter their physicochemical properties, metabolic stability, and binding affinity. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral research where fluorination is a common strategy.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atoms to enhance biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Incorporated into monomers for the production of specialty polymers with unique surface properties, chemical resistance, or optical characteristics.
• Fluorinated Liquid Crystal Research: Acts as a core component in the development of novel fluorinated liquid crystal materials for display technologies.
• PET Tracer Precursor: Potential use as a synthetic intermediate for positron emission tomography (PET) imaging agents in medical diagnostics.

Basic Information

Product Name	2,3-Difluoro-4-(trifluoromethyl)benzylamine
CAS No.	581813-21-0
Molecular Formula	C8H6F5N
Molecular Weight	211.13 g/mol
Synonyms	(2,3-Difluoro-4-(trifluoromethyl)phenyl)methanamine; 1-(Aminomethyl)-2,3-difluoro-4-(trifluoromethyl)benzene; 2,3-Difluoro-α-(trifluoromethyl)benzylamine; 4-(Trifluoromethyl)-2,3-difluorobenzylamine; 2,3-Difluoro-4-trifluoromethylbenzylamine; Benzylamine, 2,3-difluoro-4-(trifluoromethyl)-; 581813-21-0; FC-1133 (Potential research code)
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-4-(trifluoromethyl)benzylamine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality system is designed to support cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.