Description

2-Cyano-n-(4-{[(4-Methylpyrimidin-2-Yl)Amino]Sulfonyl}Phenyl)Acetamide is a high-purity, advanced pharmaceutical intermediate characterized by its unique sulfonamide-linked pyrimidine-acetamide structure. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular design. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the research and synthesis of potential drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies due to its versatile chemical scaffold.
• Biochemical Tool Compound: Employed in biochemical assays and as a probe for studying specific enzyme interactions and biological pathways.
• Contract Synthesis: A key material for CDMOs offering custom synthesis and scale-up services for pre-clinical and clinical trial material production.
• Academic Research: Utilized in university and institutional labs for exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	2-Cyano-n-(4-{[(4-Methylpyrimidin-2-Yl)Amino]Sulfonyl}Phenyl)Acetamide
CAS No.	581782-17-4
Molecular Formula	C14H13N5O3S
Molecular Weight	331.35 g/mol
Synonyms	2-Cyano-N-[4-[[(4-methyl-2-pyrimidinyl)amino]sulfonyl]phenyl]acetamide; Acetamide, 2-cyano-N-[4-[[(4-methyl-2-pyrimidinyl)amino]sulfonyl]phenyl]-; N-(4-((4-Methylpyrimidin-2-yl)sulfamoyl)phenyl)-2-cyanoacetamide; 2-Cyanoacetamide derivative with sulfonylpyrimidine; 581782-17-4; 4-((4-Methylpyrimidin-2-yl)sulfamoyl)aniline cyanoacetamide derivative
EINECS	Contact for details

Quality Control

Our 2-Cyano-n-(4-{[(4-Methylpyrimidin-2-Yl)Amino]Sulfonyl}Phenyl)Acetamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.