Description

(2-Amino-4-Trifluoromethyl-Phenyl)-Carbamic Acid tert-Butyl Ester is a high-value, protected aniline derivative and a key synthetic intermediate in advanced organic chemistry. Its core value lies in the combination of a reactive aromatic amine group, protected as a carbamate, and a trifluoromethyl substituent, which is crucial for modulating the physicochemical properties of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology, where the trifluoromethyl group enhances metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity imparted by the fluorine-containing moiety.
• Material Science Research: Serves as a monomer or precursor for advanced polymers and functional materials with specific optical or electronic properties.
• Chemical Biology & Proteomics: Employed as a scaffold or linker in the development of chemical probes and activity-based protein profiling (ABPP) agents.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific, multi-step synthetic routes.
• Academic Research: Utilized in university and institutional labs for methodological development in synthetic organic chemistry and catalysis studies.

Basic Information

Product Name	(2-Amino-4-Trifluoromethyl-Phenyl)-Carbamic Acid tert-Butyl Ester
CAS No.	579474-48-9
Molecular Formula	C12H15F3N2O2
Molecular Weight	276.26 g/mol
Synonyms	tert-Butyl (2-amino-4-(trifluoromethyl)phenyl)carbamate; N-Boc-2-Amino-4-trifluoromethylaniline; 2-Amino-α,α,α-trifluoro-p-tolylcarbamic Acid 1,1-Dimethylethyl Ester; 2-((tert-Butoxycarbonyl)amino)-4-(trifluoromethyl)aniline; Boc-2-NH2-4-CF3-Aniline; 2-Amino-4-trifluoromethylphenylcarbamic Acid tert-Butyl Ester; 4-Trifluoromethyl-2-aminophenyl tert-butylcarbamate
EINECS	Contact for details

Quality Control

Our (2-Amino-4-Trifluoromethyl-Phenyl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.