Description

3'-Chloro-4'-Fluoro-2-Biphenylamine is a high-purity biphenylamine derivative, a key organic intermediate valued for its role in constructing complex molecular architectures. Its precise halogen substitution pattern makes it a critical building block for advanced synthesis, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), crop protection agents, and specialty organic materials.

Application

• Pharmaceutical Intermediate: A crucial synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Serves as a key precursor in the development of advanced herbicides, fungicides, and insecticides, leveraging its halogenated biphenyl core.
• Material Science Research: Used in the development of organic semiconductors, liquid crystals, and other functional materials due to its rigid, substituted biphenyl structure.
• Chemical Research & Development: Employed as a versatile building block in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for creating complex biaryl systems in academic and industrial R&D.
• Dye & Pigment Intermediate: Acts as a precursor in the synthesis of specialized azo dyes and high-performance pigments.

Basic Information

Product Name	3'-Chloro-4'-Fluoro-2-Biphenylamine
CAS No.	577954-86-0
Molecular Formula	C12H9ClFN
Molecular Weight	221.66 g/mol
Synonyms	2-Amino-3'-chloro-4'-fluorobiphenyl; 3-Chloro-4-fluoro-2-biphenylamine; 2-Biphenylamine, 3'-chloro-4'-fluoro-; (3'-Chloro-4'-fluorobiphenyl-2-yl)amine; 3'-Chloro-4'-fluoro-[1,1'-biphenyl]-2-amine; 2-Amino-3'-chloro-4'-fluoro-1,1'-biphenyl
EINECS	Contact for details

Quality Control

Every batch of 3'-Chloro-4'-Fluoro-2-Biphenylamine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard specification meets the demanding requirements of pharmaceutical and fine chemical synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from direct light sources to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.