Description

6-(2-Chloro-5-Fluoropyrimidin-4-Ylamino)-2,2-Dimethyl-2H-Pyrido[3,2-B][1,4]Oxazin-3(4H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant commercial value for its role as a key building block in the synthesis of novel, targeted therapeutic agents. It is primarily required by R&D laboratories and production facilities in the pharmaceutical and biotechnology sectors engaged in developing new small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for oncology and antiviral drug candidates.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Development & Scale-Up: Serves as a standard material for optimizing synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of clinical trial materials and commercial APIs.
• Bioconjugation & Probe Development: Potential use in creating chemical probes for biochemical assays or targeted drug delivery systems due to its reactive chloro and fluoro substituents.

Basic Information

Product Name	6-(2-Chloro-5-Fluoropyrimidin-4-Ylamino)-2,2-Dimethyl-2H-Pyrido[3,2-B][1,4]Oxazin-3(4H)-One
CAS No.	575484-83-2
Molecular Formula	C₁₃H₁₂ClFN₅O₂
Molecular Weight	323.72 g/mol
Synonyms	6-[(2-Chloro-5-fluoropyrimidin-4-yl)amino]-2,2-dimethyl-2H,3H,4H-pyrido[3,2-b][1,4]oxazin-3-one; 6-(2-Chloro-5-fluoropyrimidin-4-ylamino)-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one; 575484-83-2; UNII-9J8K4F8V3R; 9J8K4F8V3R; 2H-Pyrido[3,2-b][1,4]oxazin-3(4H)-one, 6-[(2-chloro-5-fluoro-4-pyrimidinyl)amino]-2,2-dimethyl-
EINECS	Contact for details

Quality Control

Our 6-(2-Chloro-5-Fluoropyrimidin-4-Ylamino)-2,2-Dimethyl-2H-Pyrido[3,2-B][1,4]Oxazin-3(4H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent specifications required for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.