Description

Pyrido[2,3-D]Pyrimidin-7(8H)-One, 8-Cyclopentyl-5-Methyl-2-[[5-(1-Piperazinyl)-2-Pyridinyl]Amino]- is a high-purity, advanced pharmaceutical intermediate belonging to a class of fused pyrimidine derivatives. This compound is of significant value for its role as a key building block in the research and development of targeted therapeutic agents, particularly kinase inhibitors. It is primarily needed by pharmaceutical R&D laboratories, biotechnology firms, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the synthesis of novel drug candidates for oncology and other disease areas.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potent and selective kinase inhibitors for cancer therapy.
• Biochemical Research: Used as a reference standard or a tool compound in enzymatic assays and target validation studies within drug discovery pipelines.
• Medicinal Chemistry: Provides a versatile scaffold for structure-activity relationship (SAR) studies to optimize drug potency, selectivity, and pharmacokinetic properties.
• Preclinical Development: Employed in the production of batches for pharmacological and toxicological evaluation of new chemical entities (NCEs).
• Academic Research: Utilized in university and institutional labs for fundamental research on cell signaling pathways and disease mechanisms.
• Custom Synthesis: Available for contract manufacturing and custom synthesis projects requiring specific quantities and purities for proprietary drug development programs.

Basic Information

Product Name	Pyrido[2,3-D]Pyrimidin-7(8H)-One, 8-Cyclopentyl-5-Methyl-2-[[5-(1-Piperazinyl)-2-Pyridinyl]Amino]-
CAS No.	571190-22-2
Molecular Formula	C22H29N7O
Molecular Weight	407.52 g/mol
Synonyms	8-Cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one; 571190-22-2; UNII-9Q1V8I6W8I; 9Q1V8I6W8I; BDBM50164925; AKOS025310991; ZINC000003869755; A-443654 (a related analog name for context)
EINECS	Contact for details

Quality Control

Our Pyrido[2,3-D]Pyrimidin-7(8H)-One intermediate is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet client-specific requirements or internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (typically 15-25°C) in a dry environment. This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.