Description

Pyrido[2,3-D]Pyrimidin-7(8H)-One, 8-Cyclopentyl-5-Methyl-2-[[5-(1-Piperazinyl)-2-Pyridinyl]Amino]-, Hydrochloride (1:) is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value in medicinal chemistry research and development, particularly for its role as a key building block in kinase inhibitor synthesis. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of targeted therapeutics for oncology and inflammatory diseases.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel kinase inhibitors for targeted cancer therapies.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize drug candidate potency and selectivity.
• Biochemical Tool Compound: Employed in vitro to study specific kinase pathways and cellular signaling mechanisms.
• Preclinical Development: Supplied for use in the formulation and testing of new chemical entities (NCEs) during early-stage drug development.
• Contract Research & Manufacturing (CRO/CMO): Provided to organizations specializing in custom synthesis and scale-up of complex active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for fundamental research in chemical biology and drug discovery.

Basic Information

Item	Details
Product Name	Pyrido[2,3-D]Pyrimidin-7(8H)-One, 8-Cyclopentyl-5-Methyl-2-[[5-(1-Piperazinyl)-2-Pyridinyl]Amino]-, Hydrochloride (1:)
CAS No.	571189-66-7
Molecular Formula	C22H29N7O • HCl
Molecular Weight	460.0 g/mol (Free base: 423.5 g/mol)
Synonyms	8-Cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride; NVP-BEZ235 Intermediate; Dactolisib Intermediate; PI3K/mTOR Inhibitor Intermediate; BEZ235 Intermediate; 571189-66-7; UNII-7K5JLW27B2 (Hydrochloride salt form)
EINECS	Contact for details

Quality Control

Our Pyrido[2,3-D]Pyrimidin-7(8H)-One hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for each lot, and we support compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Assay (Titration)	97.0% - 103.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.