Description

Pyrido[2,3-D]Pyrimidin-7(8H)-One, 8-Cyclopentyl-6-Ethyl-2-(Methylsulfonyl)- is a high-purity, advanced pharmaceutical intermediate belonging to the pyridopyrimidinone class of heterocyclic compounds. This compound is of significant commercial interest for its role as a key building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for oncology and other therapeutic areas.
• Kinase Inhibitor Research: Used as a core scaffold in medicinal chemistry programs focused on designing and optimizing potent and selective kinase inhibitors.
• Preclinical & Clinical Development: Supplied in development quantities for use in drug discovery, process research, and the manufacture of non-GMP and GMP batches for clinical trials.
• Chemical Biology: Employed as a tool compound or a starting point for creating chemical probes to study specific biological pathways and target validation.
• Custom Synthesis: Available for custom chemical synthesis and derivatization services to create novel analogs for structure-activity relationship (SAR) studies.

Basic Information

Product Name	Pyrido[2,3-D]Pyrimidin-7(8H)-One, 8-Cyclopentyl-6-Ethyl-2-(Methylsulfonyl)-
CAS No.	571189-26-9
Molecular Formula	C15H21N3O3S
Molecular Weight	323.41 g/mol
Synonyms	8-Cyclopentyl-6-ethyl-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one; 6-Ethyl-8-cyclopentyl-2-(methylsulfonyl)-7,8-dihydropyrido[2,3-d]pyrimidin-7-one; 571189-26-9; Pyrido[2,3-d]pyrimidin-7(8H)-one, 8-cyclopentyl-6-ethyl-2-(methylsulfonyl)-; 8-Cyclopentyl-6-ethyl-2-methanesulfonyl-7,8-dihydro-3H-pyrido[2,3-d]pyrimidin-7-one
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to support regulatory filings. We are committed to consistent quality, batch-to-batch reproducibility, and full traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.