Description

6-Acetyl-8-Cyclopentyl-5-Methyl-2-[[5-(1-Piperazinyl)-2-Pyridinyl]Amino]Pyrido[2,3-D]Pyrimidin-7(8H)-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters as a critical building block in the research and development of targeted kinase inhibitors, offering significant value for medicinal chemistry programs. It is primarily needed by pharmaceutical R&D laboratories, biotechnology firms, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel kinase inhibitor drug candidates for oncology and other therapeutic areas.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Biochemical Assay Development: Serves as a reference standard or probe compound in high-throughput screening (HTS) and enzymatic assays.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and the development of robust, scalable GMP manufacturing processes.
• Academic Research: Utilized in university and institutional labs for fundamental studies on heterocyclic chemistry and drug discovery mechanisms.

Basic Information

Product Name	6-Acetyl-8-Cyclopentyl-5-Methyl-2-[[5-(1-Piperazinyl)-2-Pyridinyl]Amino]Pyrido[2,3-D]Pyrimidin-7(8H)-One Hydrochloride
CAS No.	571189-11-2
Molecular Formula	C24H29N7O2 · HCl
Molecular Weight	484.00 g/mol (Free base: 447.53 g/mol)
Synonyms	6-Acetyl-8-cyclopentyl-5-methyl-2-({5-[piperazin-1-yl]pyridin-2-yl}amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride; 571189-11-2; UNII-2F3M8G456Z; 2F3M8G456Z; CHEMBL3186660; BDBM50189319; AKOS025310923; A-770041 (Hydrochloride)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized and tested to meet stringent specifications suitable for research and development use. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We adhere to a quality management system and can support development toward cGMP standards as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.