Description

3-Chloro-5-Hydroxybenzotrifluoride is a versatile trifluoromethylated aromatic building block, prized for its unique combination of halogen and hydroxyl substituents which enable precise chemical modifications. This compound is critical for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where the introduction of fluorine atoms and specific substitution patterns is required. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in CNS and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, leveraging the trifluoromethyl group for enhanced bioactivity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a core structure in the synthesis of fluorine-containing compounds for electronic display and lighting applications.
• Polymer Modification: Acts as a functional monomer or cross-linking agent to impart specific properties like chemical resistance or altered refractive index to polymers.
• Organic Synthesis Building Block: Utilized in Suzuki, Buchwald-Hartwig, and other cross-coupling reactions to create complex, multi-substituted aromatic systems.
• Dye & Pigment Intermediate: Employed in the manufacture of specialized colorants where fluorine substitution alters lightfastness and hue.

Basic Information

Product Name	3-Chloro-5-Hydroxybenzotrifluoride
CAS No.	570391-18-3
Molecular Formula	C7H4ClF3O
Molecular Weight	196.55 g/mol
Synonyms	5-Chloro-3-(trifluoromethyl)phenol; 3-Chloro-5-(trifluoromethyl)phenol; 1-Chloro-3-hydroxy-5-(trifluoromethyl)benzene; 3-Chloro-alpha,alpha,α-trifluoro-m-cresol; 3-Chloro-5-trifluoromethylphenol; 3-Chloro-5-hydroxyphenyl trifluoromethyl ketone (common misnomer); m-Chloro-m-trifluoromethylphenol
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-Hydroxybenzotrifluoride is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets exacting standards for research and production. Certificates of Analysis (COA) with full traceability are provided for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.