Description

3-Formyl-5-(Trifluoromethyl)Benzonitrile is a high-purity, multi-functional aromatic building block featuring both a formyl and a nitrile group on a trifluoromethyl-substituted benzene ring. This unique structure makes it an exceptionally versatile intermediate for synthesizing complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought after by R&D chemists and process development scientists for constructing active pharmaceutical ingredients (APIs), advanced materials, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, and oncology, leveraging the trifluoromethyl group for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl moiety often contributes to improved pesticidal activity and environmental profile.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Advanced Material Research: Employed in the synthesis of monomers and functional units for specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Utilized to build molecular probes and tags for studying biological processes and target engagement.

Basic Information

Product Name	3-Formyl-5-(Trifluoromethyl)Benzonitrile
CAS No.	569370-39-4
Molecular Formula	C9H4F3NO
Molecular Weight	199.13 g/mol
Synonyms	5-(Trifluoromethyl)isophthalonitrile aldehyde; 3-Cyano-5-(trifluoromethyl)benzaldehyde; 5-(Trifluoromethyl)-1,3-benzenedicarbonitrile, 1-oxide (related); Isophthalonitrile, 5-(trifluoromethyl)-, 1-oxide; 3-Formyl-5-trifluoromethylbenzonitrile; 3-Cyano-5-trifluoromethylbenzaldehyde; 5-(Trifluoromethyl)isophthalaldehyde mononitrile
EINECS	Contact for details

Quality Control

Our 3-Formyl-5-(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and lot-to-lot consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with cGMP and ICH Q7 guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening containers to maintain purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.