Description

Fmoc-Aeea-Aeea CAS NO 560088-89-3 is a specialized, high-purity peptide coupling reagent featuring two consecutive 8-amino-3,6-dioxaoctanoic acid (Aeea) spacer units protected by a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is essential for introducing hydrophilic, flexible polyethylene glycol (PEG)-like linkers into peptide and peptidomimetic structures, significantly enhancing solubility and reducing aggregation. It is a critical building block for researchers and manufacturers in pharmaceutical development, bioconjugation, and advanced drug delivery systems, particularly for creating antibody-drug conjugates (ADCs) and therapeutic peptides.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected building block for introducing flexible, hydrophilic PEG-based spacers during automated or manual peptide assembly.
• Antibody-Drug Conjugate (ADC) Linker Technology: For constructing the bridge between cytotoxic payloads and monoclonal antibodies, improving pharmacokinetics and stability.
• Peptidomimetic & Constrained Peptide Design: To incorporate solubility-enhancing elements and control the spatial orientation of functional groups in novel bioactive compounds.
• Bioconjugation and Labeling: For attaching dyes, probes, or other molecules to peptides, proteins, or surfaces while maintaining aqueous solubility.
• Drug Delivery System Development: As a component in the design of prodrugs and nanocarrier systems where controlled spacing and hydrophilicity are required.
• Research & Development: For academic and industrial R&D focused on novel therapeutic modalities, including targeted cancer therapies and diagnostic agents.

Basic Information

Product Name	Fmoc-Aeea-Aeea
CAS No.	560088-89-3
Molecular Formula	C31H40N2O9
Molecular Weight	584.66 g/mol
Synonyms	Fmoc-8-amino-3,6-dioxaoctanoic acid-8-amino-3,6-dioxaoctanoic acid; Fmoc-AEEA-AEEA-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-8-amino-3,6-dioxaoctanoic acid-8-amino-3,6-dioxaoctanoic acid; Fmoc-NH-(CH2CH2O)2-CH2CH2COOH-(CH2CH2O)2-CH2CH2COOH; Fmoc-dPEG®2-acid-dPEG®2-acid; Fmoc-PEG2-PEG2-acid; (2-{2-[2-(2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}ethoxy)ethoxy]acetylamino}ethoxy)acetic Acid
EINECS	Contact for details

Quality Control

Our Fmoc-Aeea-Aeea is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.