Description

8-(Allyloxycarbonyl-Amino)-3,6-Dioxaoctanoic Acid Dicyclohexylamine (Aloc-Ado*Dcha, Aloc-Aeea*Dcha) is a specialized, high-purity chemical building block designed for advanced organic synthesis. This compound matters because it provides a protected, reactive handle for the controlled introduction of functional groups, particularly in the synthesis of complex peptides, linkers, and bioconjugates. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require reliable, high-quality intermediates for developing novel therapeutics and diagnostic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key intermediate for introducing polyethylene glycol (PEG)-like spacer arms (AEEA) with an Aloc-protected amine, enabling orthogonal deprotection strategies.
• Bioconjugation and Linker Chemistry: For creating cleavable or non-cleavable linkers in antibody-drug conjugates (ADCs), peptide-drug conjugates, and other targeted delivery systems.
• Functional Material Synthesis: In the preparation of functionalized polymers, hydrogels, and surfaces where a hydrophilic spacer and a protected amine group are required for subsequent coupling.
• Protecting Group Strategy: Utilized in multi-step organic synthesis where the Aloc (allyloxycarbonyl) protecting group can be selectively removed under mild, neutral conditions in the presence of other common protecting groups.
• Research & Development: Serves as a critical reagent in academic and industrial R&D for exploring new synthetic pathways and bioactive molecule construction.

Basic Information

Item	Details
Product Name	8-(Allyloxycarbonyl-Amino)-3,6-Dioxaoctanoic Acid Dicyclohexylamine
CAS No.	560088-74-6
Molecular Formula	C24H42N2O6
Molecular Weight	454.60 g/mol
Synonyms	Aloc-AEEA-OH DCHA Salt; Aloc-Ado-OH DCHA Salt; Nα-Aloc-8-amino-3,6-dioxaoctanoic acid dicyclohexylamine salt; Fmoc-8-amino-3,6-dioxaoctanoic acid Aloc derivative; Aloc-NH-PEG2-COOH DCHA salt; 2-[2-[2-(Allyloxycarbonylamino)ethoxy]ethoxy]acetic acid dicyclohexylamine salt; Aloc-AEEA DCHA; Aloc-Ado(Dcha)
EINECS	Contact for details

Quality Control

Every batch of Aloc-Ado*Dcha is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical research and production. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, purity by HPLC, and identity confirmation. Our commitment to quality assurance supports compliance in cGMP environments and ensures batch-to-batch consistency for your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the Certificate of Analysis. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.