Description

Ethanone, 2-Chloro-1-(2-Pyrimidinyl)- (9Ci) is a high-purity, specialized organic building block featuring a reactive chloromethyl ketone group adjacent to a pyrimidine heterocycle. This molecular architecture makes it a critical intermediate for the synthesis of complex molecules in advanced research and development. It is primarily sought after by pharmaceutical and agrochemical R&D teams for constructing novel active ingredients, including kinase inhibitors and other biologically relevant heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor programs targeting cancer and inflammatory diseases.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the pyrimidine moiety for bioactivity.
• Chemical Biology & Medicinal Chemistry: Serves as a versatile electrophile in structure-activity relationship (SAR) studies and probe molecule synthesis.
• Material Science Precursor: Potential building block for advanced organic materials, such as ligands for metal-organic frameworks (MOFs) or functional polymers.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	Ethanone, 2-Chloro-1-(2-Pyrimidinyl)- (9Ci)
CAS No.	556025-72-0
Molecular Formula	C6H5ClN2O
Molecular Weight	156.57 g/mol
Synonyms	2-Chloro-1-(pyrimidin-2-yl)ethan-1-one; 2-Chloro-1-(2-pyrimidinyl)ethanone; 2-Pyrimidinyl Chloromethyl Ketone; 1-(2-Pyrimidinyl)-2-chloroethanone; 2-Chloro-1-(pyrimidin-2-yl)ethanone; α-Chloro-2-pyrimidyl methyl ketone; 2-Chloro-2-pyrimidin-1-ylethanone
EINECS	Contact for details

Quality Control

Our Ethanone, 2-Chloro-1-(2-Pyrimidinyl)- (9Ci) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques (HPLC, GC, NMR). We support cGMP compliance for advanced intermediates and can provide material for regulatory filings upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.